Senior/Principal Scientist, Medicinal Chemistry – Peptide Drug Design

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Senior/Principal Scientist, Medicinal Chemistry – Peptide Drug Design
Level: Senior Scientist to Associate Director | ByteDance 3-1 / 3-2 Equivalent
Location: Flexible – United States or China
About Our Client
Our Client is a clinical-stage biotech company redefining peptide therapeutics through the integration of AI-driven design, novel chemistry, and translational biology. Backed by [top-tier investors/partners], we are advancing a pipeline of First-in-Class (FIC) programs targeting [oncology, metabolic, immunology — insert TAs] with high unmet need.
We combine the scientific rigor of Big Pharma with the speed and ownership of a startup. Our team is distributed across the US and China, united by one goal: deliver breakthrough medicines to patients, faster.
The Role
We are seeking a Senior or Principal Scientist / Associate Director in Medicinal Chemistry to lead peptide drug discovery from concept to candidate. You will own the chemistry strategy for FIC programs and work shoulder-to-shoulder with computational, biology, and translational teams to compress timelines from idea to IND.
What You'll Own

- Lead design and optimization of First-in-Class peptide therapeutics against novel, high-value targets

- Drive SAR campaigns across macrocycles, stapled peptides, peptide-drug conjugates, and oral bioavailable peptides

- Partner with AI/ML, CADD, structural biology, DMPK, and pharmacology to run rapid design-make-test cycles

- Advance programs through hit-to-lead, lead optimization, and IND-enabling studies

- Represent Medicinal Chemistry on core project teams and mentor junior scientists

What You Bring

- PhD in Organic Chemistry, Medicinal Chemistry, Chemical Biology, or related field

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8+ years industry experience at major U.S. pharmaceutical companies , with peptides/proteins taken to IND/clinic

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Startup experience : Thrive in agile, ambiguous environments with high ownership and urgency

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ByteDance Level 3-1 to 3-2 equivalent — Senior Scientist, Principal Scientist, or Associate Director scope

- Deep expertise in peptide design: non-canonical amino acids, cyclization, conjugation, SBDD, and peptide property optimization

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Proven FIC track record : Invented novel mechanisms of action and advanced them into development

Why Join Our Client

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Real shots on goal : Work on FIC programs with line of sight to patients

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Speed + Resources : Startup velocity, backed to move programs to the clinic

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Global + Flexible : Base in US or China, collaborate with world-class talent

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Top-tier package : Competitive comp, significant equity, and comprehensive benefits

Originally posted on Himalayas