Associate Scientist 2 - Assay R&D #4992

Our mission is to detect cancer early, when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative, safe, and effective technologies that can transform cancer care.

We are a healthcare company, pioneering new technologies to advance early cancer detection. We have built a multi-disciplinary organization of scientists, engineers, and physicians and we are using the power of next-generation sequencing (NGS), population-scale clinical studies, and state-of-the-art computer science and data science to overcome one of medicine’s greatest challenges.

GRAIL is headquartered in the Bay Area of California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies.

For more information, please visit grail.com

The Associate Scientist 2 is a developing professional role that applies growing scientific expertise to independently execute standard laboratory procedures and contribute to more complex research activities. This position performs molecular biology, protein expression, purification, and related analytical techniques with increasing autonomy, ensuring accuracy, compliance, and high-quality documentation. The Associate Scientist 2 advances research objectives by applying professional judgment within established scientific and operational frameworks, supporting data interpretation, and contributing to the overall effectiveness of the laboratory environment.

This role is based in Durham, North Carolina, and requires full-time on-site attendance at GRAIL's Research Triangle Park (RTP) laboratory (4001 E NC 54 HW Assembly Suite 1100, Durham, NC 27709).

Responsibilities:

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Perform a range of established laboratory experiments using professional methods in molecular biology, including RNA isolation, genomic DNA isolation, cDNA preparation, cloning, fermentation, protein expression, and purification with increasing independence and accuracy.

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Prepare, process, and analyze samples, reagents, buffers, and media for experimental workflows while applying professional judgment to ensure precision, proper documentation, and procedural compliance.

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Collect, interpret, and document experimental data in laboratory notebooks or electronic systems using professional data management practices that support reproducibility and scientific integrity.

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Operate, maintain, and perform routine troubleshooting on laboratory equipment, identifying issues that require escalation and ensuring continuous readiness of instruments used in scientific work.

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Assist in refining laboratory protocols or methods by providing professional observations on workflow efficiency, data quality, and opportunities for procedural improvement.

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Contribute to the preparation of technical reports, data summaries, protocol drafts, and quantitative analyses to support scientific communication and project decision-making.

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Ensure adherence to safety, regulatory, and quality standards in the handling of chemical and biological materials, demonstrating accountability for maintaining a professional laboratory environment.

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Support laboratory operations through inventory oversight, organization of materials, coordination of supply needs, and contributions to continuous process improvements.

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Provide informal guidance and technical support to junior laboratory staff by sharing professional knowledge, reinforcing documentation standards, and modeling effective laboratory practices.

- These job duties are a summary of the primary duties and responsibilities of the job and position. It is not intended to be a comprehensive or all-inclusive listing of duties and responsibilities. Contents are subject to change at the company's discretion.

Adaptability and Growth Expectation:

As our organization continues to evolve and grow, this role may require flexibility in responsibilities and duties.  Employees should expect that their role may expand, shift, or be modified to meet changing business needs, strategic priorities, and organizational objectives.

This may include:

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Taking on additional responsibilities.

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Participating in cross functional projects and initiatives.

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Adapting to new technologies, processes, or methodologies.

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Supporting other departments or teams during periods of high demand.

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Contributing to special projects or temporary assignments as needed.

Required Qualifications:

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Bachelor’s degree in Biology, Chemistry, Biochemistry, or related scientific discipline with 2–5 years of relevant experience; OR Master’s degree in a related field with 0–2 years of relevant experience.

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Demonstrated level of knowledge regarding applicable regulatory standards commensurate with the position's complexity and scope, contributing to organizational regulatory compliance. Minimal applicable standards for this position include:

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GMP quality management systems (e.g. ISO 13485)

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Operations within the regulated medical device environment (e.g. IVDD, IVDR, FDA 21 CFR 800 series, FDA 21 CFR Part 11)

Preferred Qualifications:

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Solid technical proficiency in standard laboratory techniques and equipment operation.

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Ability to analyze data, identify issues, and communicate findings clearly.

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Strong organizational and problem-solving skills with attention to detail.

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Effective communication skills, both written and verbal.

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Ability to work both independently and collaboratively within a team environment.

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Familiarity with laboratory documentation systems, data management tools, and reporting processes.

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Knowledge of laboratory safety practices, compliance requirements, and quality standards.

Physical Demands and Environment:

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Work is primarily performed in a laboratory environment with exposure to biological, chemical, or hazardous materials.

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Routine use of PPE including lab coats, gloves, and safety glasses is required.

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Involves prolonged periods of standing, pipetting, and handling laboratory materials.

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May occasionally require evening or weekend work to meet project demands.

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Operates under moderate supervision with periodic review of work products and outcomes.

The expected, full-time, annual base pay scale for this position is $ 82,000 - $102,000 in Durham, NC

At GRAIL, we believe in recognizing and rewarding the contributions our employees make to our mission and success. In addition to base pay, this role may be eligible for additional compensation, including an annual bonus and/or other incentives, in accordance with applicable plans and the company's discretion. The posted range reflects our good-faith estimate of the base pay we expect to offer for this position at the time of hire. Actual compensation will be determined based on factors such as the candidate’s experience, skills, qualifications, and other relevant considerations.

At GRAIL, we invest in the health, well-being, and future of our employees and their families. Employees in this role are eligible for a comprehensive and competitive benefits package designed to support what matters most, including flexible time off or vacation, a 401(k) retirement plan with employer match, medical, dental, and vision coverage, and thoughtfully selected well-being programs. Benefits are offered in accordance with applicable plans and policies.

GRAIL is an equal employment opportunity employer, and we are committed to building a workplace where every individual can thrive, contribute, and grow. All qualified applicants will receive consideration for employment without regard to race, color, religion, national origin, sex, gender, gender identity, sexual orientation, age, disability, status as a protected veteran, or any other class or characteristic protected by applicable federal, state, and local laws. Additionally, GRAIL will consider for employment qualified applicants with arrest and conviction records in a manner consistent with applicable law and provide reasonable accommodations to qualified individuals with disabilities. Please contact us at rc@grailbio.com if you require an accommodation to apply for an open position.

GRAIL maintains a drug-free workplace. We welcome job-seekers from all backgrounds to join us!

Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment qualified applicants with arrest and conviction records.